Painful urination (dysuria) is pain or burning with urination, usually felt in the tube that carries urine out of your bladder (urethra) or the area surrounding your genitals (perineum). Anyone may experience bouts of painful urination. Painful urination is the most common symptom of a urinary tract infection, especially in women. In men, urinary tract infections are less common, so painful urination is most commonly caused by urethritis and certain prostate conditions.